Phospho-Signaling at Oocyte Maturation and Fertilization: Set Up for Embryogenesis and Beyond Part II. Kinase Regulators and Substrates
نویسندگان
چکیده
Filamentous actin or F-actin is a major component of stress fibers and involved in cellular architecture. Its dynamic rearrangement supports not only cellular morphology but also intracellular signal transduction that regulate cell-cell or cell-extracellular matrix interactions, cell motility, and proliferation. Several lines of evidence demonstrate that, in several organisms, oocyte cortical cytoskeleton involving F-actin network undergoes a dynamic rearrangement during meiosis/oocyte maturation and that this is often involving phosphorylation of actin and/or actin-interacting proteins (e.g. ADF/coffilin, see below) catalyzed by PKC (in Tubifex, Xenopus) (Capco et al. 1992; Shimizu 1997). In Drosophila, PKC phosphorylation of a tumor suppressor protein-homolog named Lgl (lethal (2) giant larvae) is responsible for actin-dependent oocyte polarity formation (Tian and Deng 2008). In mammalian oocytes (rat), F-actin has been implicated in tyrosine kinase-dependent
منابع مشابه
Phospho-Signaling at Oocyte Maturation and Fertilization: Set Up for Embryogenesis and Beyond Part I. Protein Kinases
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